Obagi Nu Cil Eyelash Enhancing Serum: Is It Worth The Hype?

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Obagi Nu Cil

Looking to rock lush, voluminous lashes and wondering if the viral Obagi Nu Cil Eyelash Enhancing Serum is worth trying?

This TikTok-approved eyelash serum is winning over the beauty world for delivering impressive (magical, almost?) results. And we’re not just talking about longer lashes. The serum is clinically proven to result in thicker and darker lashes in 16 weeks!

You’re probably thinking, “That’s fab! Will it work for me?”

A stylized shot of the Obagi Nu Cil Eyelash Enhancing Serum, one of the most effective eyelash growth products.

Source: Obagi

Here at Haul of Fame, we’re big fans of research-backed beauty finds. Tap into our signature research process to see if the Obagi Nu Cil Eyelash Enhancing Serum might be a good fit for your skincare routine.

There’s also a lot of talk in the beauty space today about eyelash serum side effects, so we’ll walk you through that, plus the key ingredients as well as reviews on this best selling Obagi product.

Let’s get into it!

What Is The Obagi Nu Cil Eyelash Enhancing Serum?

A row of Nu Cil Obagi eyelash enhancing products.

Source: Obagi 

It’s the superstar eyelash growth serum by clinical skin care brand Obagi Medical. It’s fast gaining cult-favorite status for delivering on its promise: longer, thicker, and darker lashes.

If you’re a fan of Obagi, you’ll know that they’re big on science-based skincare. Part of what makes this eyelash serum stand out is the impressive clinical trial stats.

We spoke to Aesthetics Doctor, Dr Kazim Dhanji to get his intel on Obagi and particularly the benefits of the Nu-Cil serum:

From a clinician’s perspective, Obagi products are fantastic. They have an excellent track record of delivering proven results. This gives us confidence that, when we recommend them to our patients, they are going to get the results they are seeking. In turn our patients trust us and the products that we recommend!

Dr Kazim Dhanji, KHD Aesthetics

Based on a 16-week blinded study in 2021, these were the results of using the Obagi Nu Cil Eyelash Enhancing Serum:

  • 93% of participants said their eyelashes showed visible improvement
  • 89% of participants said their eyelashes looked thicker
  • 89% of participants said their eyelashes looked more densely packed

Before we get into more details about the Obagi Nu Cil Eyelash Enhancing Serum and whether it’s really worth the hype, let’s cover some basics you might want to know about eyelash serums.

What is eyelash growth serum? And should you be using it?

Eyelash growth serums are becoming the go-to pick for those looking to get fuller-looking lashes.

We might be genetically prone to short and sparse lashes, or perhaps we’ve noticed our lashes over time are lacking the volume and depth they used to have. Either way, that’s where eyelash growth serums come in to work their magic.

Lash enhancing serums contain active ingredients like biotin and hyaluronic acid to naturally boost lash growth. If you notice your lashes looking a little lackluster lately, eyelash grower serums are an option to restore lush-looking lashes.

Key Ingredients In The Obagi Nu Cil Eyelash Serum 

A profile shot of the Obagi Nu Cil Eyelash Enhancing Serum to illustrate key ingredients in the lash serum.

Source: Obagi 

What sets the Obagi Nu Cil eyelash serum apart from similar products is its unique NouriPlex™ Technology. It’s a blend of 4 key ingredients clinically proven to support overall lash improvement.

These are the active ingredients that make up the Obagi Nu Cil eyelash serum formula:


This water-soluble vitamin is associated with healthy hair and nail growth, and is a common ingredient in eyelash-boosting serums. 

Biotin helps achieve thicker and fuller lashes by supporting the production of keratin.

“Biotin supplements have long been used to strengthen hair and fingernails. Applying a biotin containing serum directly to the eyelash should help strengthen the hair by supporting the production of keratin.”

Dr Kazim Dhanji, KHD Aesthetics

Hyaluronic Acid

This serum staple is known for its ultra-moisturizing properties. Hyaluronic acid promotes healthy-looking lashes by promoting healthy hydration.

Hyaluronic acid is the principle ingredient in dermal fillers and is known for its ability to draw in large amounts of water, which helps to reduced lines and wrinkles and keep the skin moisturised. Applying a hyaluronic acid containing serum to eyelashes should provide moisture in order to make the lashes look more voluminous.

Dr Kazim Dhanji, KHD Aesthetics


This precursor to vitamin B5 is excellent at locking in moisture. It gives lashes a natural softness and beautiful shine.


This proprietary lipid compound targets the anagen phase of the lash cycle – it’s the part where lashes actively grow.

This growth boost helps to achieve thicker, more dramatic-looking eyelashes.

Is dehydrolatanoprost a prostaglandin? Yup, it is. Before getting the Obagi Nu Cil eyelash serum, you’ll need to decide if you’re okay with an eyelash serum that contains prostaglandin.

Does Obagi Nu Cil Have Prostaglandin?

Yes, the Obagi Nu Cil eyelash serum contains dehydrolatanoprost, which is a type of prostaglandin.

Prostaglandin is a common ingredient in eyelash serums today, but it was originally used to treat glaucoma and ocular hypertensive patients.

How do the two connect to each other?

Well, the patients using the medication started sporting thicker and fuller-looking lashes! Bimatoprost, another type of prostaglandin, was eventually relaunched as Latisse. It became the first FDA-approved treatment for sparse lashes.

Lowering prostaglandin analogs are the secret sauce for effective eyelash growth products. They disrupt the lash cycle, boosting the anagen growth phase which results in longer and thicker lashes.

Prostaglandins also stimulate the production of melanin, resulting in darker lashes.

Although eyelash serums containing prostaglandins tend to be effective, they’re also associated with potential side effects.

Obagi Nu Cil Lash Serum: Safety & Possible Side Effects

A woman shows how to apply Obagi eyelash serum.

Source: Obagi 

Being one of the top medical-grade skincare brands in the United States, Obagi Medical products are generally regarded as safe for all skin types. Obagi’s eyelash-enhancing serum is physician-endorsed and ophthalmologist-tested to give you 100% real lashes.

That being said, these are the possible side effects highlighted by the brand:

Redness / Itchiness

Eye irritation is a possibility when using the eyelash serum. Allergic reactions can happen too so get the okay from your physician before using.

Once you’ve applied the lash serum, wipe off any excess to avoid it from getting into the eyes and causing irritation. Avoid applying the serum on the lower lashes. It gets into the eye easier and can result in redness and itchiness.

Increased Brown Iris Pigmentation

This answers one of the biggest questions about this eyelash serum: Does Obagi Nu Cil change your eye color?

Using eyelash serums containing prostaglandins might result in the darkening of your eye color. Although rare, it can happen and it has a permanent effect so that’s definitely something to consider – especially if you have lighter-colored eyes.

Darkening Of Eyelid Skin

Remember how prostaglandins will do their thing to stimulate melanin for darker lashes? That same mechanism might cause hyperpigmentation of the eyelids. Yikes!

Eye Infections

As with any eye product, using an eyelash serum can increase the chances of getting an infection in this delicate area.

Always be extra careful with what the tip of the wand comes in contact with. If the product frequently touches unsanitary items and areas, your eyes will be at a high risk for infections.

What Are People Saying About The Obagi Nu Cil Lash Serum?

A focused shot of two women’s eyes to illustrate Obagi eyelash growth serum reviews.

Reviews on the Obagi Nu Cil lash serum are mostly positive, winning users over with its effectiveness.

Here’s what people are saying about this wonder serum:

“I’m super impressed. The brand says you can see results as early as 8 weeks but I saw a significant difference in just three weeks! There are so many eyelash serums on the market but this one actually delivered results.” 

– Ashley

“Definitely worth every penny (the eyebrow boosting serum too!). No prescription needed but you get prescription results in about 3 weeks.”

– sjc

“I took photos of before and after the eyelash serum and I’m certain my eyelashes are substantially longer. I’m comparing this Obagi eyelash serum vs Latisse and I believe this product works better. Will continue to use it.”

– Happy Viola

Read more Amazon reviews on the Obagi Nu Cil Eyelash Enhancing Serum.

Is The Obagi Nu Cil Lash Serum Worth The Hype?

That depends on what you’re looking for in an eyelash serum.

If you’re on the lookout for eyelash enhancing products that deliver on their promise for longer, thicker, and darker lashes, the Obagi Nu Cil Eyelash Enhancing Serum is definitely a worthy contender (see Obagi lash serum before and after image below with expert grading assessment scores).

Obagi lash serum before and after
Source: Obagi

The unique enhancing components of the brand’s NouriPlex Technology sets it apart in most eyelash growth serum comparisons, giving the Obagi Nu Cil an edge in effectiveness.

If you’re specifically looking for prostaglandin-free eyelash serums, the Obagi Nu Cil Eyelash Enhancing Serum isn’t going to be the best fit for you as it contains dehydrolantanoprost.

Consider going for peptides-based eyelash serums if you want a more natural, prostaglandin-free option. These protein-packed serums are generally regarded as a safer pick. The peptides in the serum promote lash growth and strength.

If you want an alternative to eyelash serums, try the best natural oils for eyelash growth.

How To Apply Obagi Eyelash Serum

This eyelash serum can only work its magic with proper application. Here’s the simple 2-step guide on how to apply the serum:

Step 1: On cleansed skin, apply a thin layer of the serum to the upper eyelid margins. 

Step 2: Let the serum dry for at least 90 seconds before applying other products.

And that’s about it!

Here’s a visual guide on applying the serum:

Use the serum regularly every day for 16 weeks to get the best results. You can pair your eyelash growth routine with the top-rated Obagi Elastiderm Eye Cream for an anti-aging boost to smooth skin fine lines and wrinkles around the eye area.

Keep these things in mind when applying the serum:

  • It’s best to apply the serum at night as part of your evening skin care routine. The serum is meant to be left on overnight.
  • The serum is meant for the upper lash line only. Don’t apply to your lower lashes or any other areas of the eye.
  • Discontinue product usage if you notice new ocular conditions (dry eyes or infections, for example) when using the serum.

It’s super important to be sure that the product is safe for you, so it’s a good idea to check with your physician before use. Definitely speak with your doctor if you’re pregnant or breastfeeding, or if you’re undergoing treatment for cancer or eye-related conditions.

Where To Shop For The Obagi Nu Cil Eyelash Enhancing Serum

Some best-selling Obagi Medical skin care products are only available via prescription. This doesn’t apply to the Obagi Nu Cil Eyelash Enhancing Serum (if you’re based in the US) which is available to purchase directly online.

If you’re in the UK however, you’ll need a prescription for this. Speak to your GP or a registered dermatologist.

A profile shot of the Obagi Nu Cil Eyelash Enhancing Serum. Shop at serum regular price or at a discount.

Can You Use The Obagi Nu Cil Lash Serum On Eyebrows?

Scroll through the Obagi Nu Cil eyelash growth serum reviews and you’ll see mentions of this lash serum being used on eyebrows.

If you’re specifically looking for an eyebrow serum, we recommend checking out the Obagi Nu Cil Eyebrow Boosting Serum.

A few tubes of the Obagi Nu Cil Eyebrow Boosting Serum are held in hand.

Source: Obagi

The eyebrow boosting serum is formulated for thinning and over-tweezed brows using the same NouriPlex Technology, and comes with a brow-appropriate applicator.

Based on Obagi eyebrow serum before and after reviews, it seems to be just as effective as the eyelash serum!

Obagi also sell the Nu-Cil Eyelash Enhancing Serum and Eyebrow Boosting Serum as a set if you wanted to treat yourself to both!

Frequently Asked Questions: Obagi Nu Cil Eyelash Enhancing Serum

How Long Does It Take For Obagi Nu Cil To Work?

It takes about 16 weeks for the Obagi Nu Cil lash serum to work. Based on user reviews, you may start to see a difference after 8 weeks.

Keep in mind that the product needs consistent, daily use for it to result in longer, thicker, and darker lashes within the time frame.

What Is The Active Ingredient In Obagi Nu Cil?

The active ingredient in Obagi Nu Cil is NouriPlex Technology. It’s the brand’s proprietary blend of biotin, hyaluronic acid, panthenol, and dehydrolantanoprost.

The combination of these active ingredients covers all the bases for fuller-looking lashes. NouriPlex Technology targets the anagen phase to boost growth while supporting keratin production and keeping the lashes hydrated.

What Are The Side Effects Of Obagi Nu Cil Eyelash Serum?

These are the potential side effects of Obagi Nu Cil Eyelash Serum:

  • Dry eyes
  • Redness / itchiness
  • Increased brown iris pigmentation
  • Darkening of eyelid skin
  • Eye infection
  • Allergic reactions

What Happens When You Stop Using Lash Serum?

When you stop using lash serum, your lashes will eventually revert to the natural growth cycle. If you had shorter and thinner lashes before starting to use the serum, once you stop using the serum you can expect your lashes to gradually return to this look.

Does Lash Serum Age Your Eyes?

It’s possible that lash serums can eventually create an aged look to your eyes.

Some lash serums are associated with deepening of upper eyelids and fat loss around the eye area. The effect is the permanent premature aging of the eyelids.

Can You Put Lash Serum On Your Bottom Lashes?

No, you can’t put lash serum on your bottom lashes. Apply lash serum to the upper lash line only. This reduces the chances of the product getting into the eye, which is likely to increase the chances of experiencing side effects.

How Long Does Obagi Eyelash Serum Last?

A tube of Obagi eyelash serum lasts 2-3 months. This is based on daily use on the upper lash line.

To stay the course for the recommended 16-week time period, you can plan ahead and shop for 2 tubes. 

Does Obagi Lash Serum Contain Prostaglandins?

Yes, the Obagi lash serum contains prostaglandins. Dehydrolantanoprost, an active ingredient in this lash serum, is a type of prostaglandin.

Prostaglandins are a common ingredient in lash serums as they target the anagen phase of the lash cycle and boosts growth, increasing the effectiveness of the serums.

Can You Use Obagi Nu Cil On Eyebrows?

You can use the Obagi Nu Cil eyebrow serum on eyebrows. Obagi Nu-Cil Eyebrow Boosting Serum accentuates the healthy look of fuller, denser, darker appearing brows. 

Obagi Nu Cil products, including this eyebrow boosting serum, uses the proprietary NouriPlex Technology, a blend of 4 active ingredients to revive thinning, patchy, and over-tweezed brows.

What Is The Best Lash Serum For Growth?

The Obagi Nu Cil lash serum is one of the top eyelash growth serums thanks to its unique NouriPlex Technology. This unique blend of biotin, hyaluronic acid, panthenol, and dehydrolantanoprost sets it apart from other lash serums.

Is It Better To Put Lash Serum On At Night Or In The Morning?

It’s better to put lash serum on at night before bedtime. Lash serums need time to be absorbed into the lashes. Ideally, it’s best to apply it during your evening skin care routine and leave it overnight.

Do You Put Mascara Over Lash Serum?

You can put mascara over lash serum. Just remember that you should always apply the lash serum before mascara – never the other way around.

Applying the lash serum first gives it time to dry and be absorbed by the lashes. Applying lash serum after mascara makes it hard to be absorbed, and it might run from coming in contact with the wet mascara.

Should I Wash My Lash Serum Off In The Morning?

No, you don’t have to wash your lash serum off in the morning. Lash serums are meant to be left on the lashes overnight – there’s no need to wash them off.

You can kickstart your morning skin care routine by cleansing as you normally would. There aren’t any specific cleansing steps you need to add when using lash serums.

Obagi Nu Cil Eyelash Enhancing Serum: Summary

A stylized shot of top eyelash growth serum, the Obagi Nu Cil Eyelash Enhancing Serum.

Source: Obagi

Is the Obagi Nu Cil Eyelash Enhancing Serum worth the hype? 

Obagi’s eyelash enhancer serum is worth trying if you’re looking for an eyelash growth serum that works! 

Backed by clinical trials and glowing reviews, you’re likely to see dramatic results with proper usage of this effective long lashes serum.

Keep in mind that Obagi Nu Cil lash serum contains prostaglandins, and that comes with potential side effects.

Planning to give the Obagi Nu Cil Eyelash Enhancing Serum a try? Share your experience with us in the comments!

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  1. Obagi eyelash serum is my favorite. I’ve been using it for a while now and did notice a boost in the volume and length of my lashes.

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